Dataset Information


Conserved roles of glucose in suppressing reactive oxygen species-induced cell death and animal survival.

ABSTRACT: Carbohydrate overconsumption increases blood glucose levels, which contributes to the development of various diseases including obesity and diabetes. It is generally believed that high glucose metabolism increases cellular reactive oxygen species (ROS) levels, damages insulin-secreting cells and leads to age-associated diabetic phenotypes. Here we find that in contrast, high glucose suppresses ROS production induced by paraquat in both mammalian cells and the round worm C. elegans. The role of glucose in suppressing ROS is further supported by glucose's ability to alleviate paraquat's toxicity on C. elegans development. Consistently, we find that the ROS-regulated transcription factor SKN-1 is inactivated by glucose. As a result, the ROS/SKN-1-dependent lifespan extension observed in paraquat-treated animals, mitochondrial respiration mutant isp-1 and germline-less mutant glp-1 are all suppressed by glucose. Our study reveals an unprecedented interaction of glucose with ROS, which could have significant impact on our current understanding of glucose- and ROS-related diseases.


PROVIDER: S-EPMC6710067 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC6286829 | BioStudies
2017-01-01 | S-EPMC5497675 | BioStudies
2012-01-01 | S-EPMC4844853 | BioStudies
2017-01-01 | S-EPMC5493208 | BioStudies
2015-01-01 | S-EPMC4335496 | BioStudies
2021-01-01 | S-EPMC7906160 | BioStudies
2010-01-01 | S-EPMC2998438 | BioStudies
2016-01-01 | S-EPMC4878494 | BioStudies
1000-01-01 | S-EPMC5676065 | BioStudies
1000-01-01 | S-EPMC2836976 | BioStudies