Unknown

Dataset Information

0

Seeing is believing: our evolving view of kinetochore structure, composition, and assembly.


ABSTRACT: This review highlights three recent trends in the field of kinetochore biology: the proliferation of structural data for kinetochore protein complexes (including CBF3, Dam1c, Mis12cMIND, and CENP-NLChl4/Iml3); the growing consensus that the kinetochore is a dynamic structure whose composition changes as the cell cycle progresses; and the mounting evidence of multiple pathways whereby the microtubule-binding elements of the outer kinetochore may be recruited by inner kinetochore proteins. Our focus is on the two best-studied systems in the field: human and budding yeast kinetochores. This review will demonstrate the remarkable similarity of these two systems, as well as their intriguing differences.

SUBMITTER: Hamilton G 

PROVIDER: S-EPMC6756984 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

1998-01-01 | S-EPMC2132809 | BioStudies
2019-01-01 | S-EPMC6781445 | BioStudies
1000-01-01 | S-EPMC2890832 | BioStudies
1000-01-01 | S-EPMC452590 | BioStudies
1000-01-01 | S-EPMC3542802 | BioStudies
2018-01-01 | S-EPMC5771398 | BioStudies
2010-01-01 | S-EPMC2909587 | BioStudies
2014-01-01 | S-EPMC6377234 | BioStudies
1000-01-01 | S-EPMC5080440 | BioStudies
1000-01-01 | S-EPMC2064494 | BioStudies