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Catalytic Asymmetric Synthesis of Diketopiperazines by Intramolecular Tsuji-Trost Allylation.


ABSTRACT: We report the intramolecular Tsuji-Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asymmetric construction of a broad range of these medicinally important heterocycles under mild conditions, in two steps from cheap, commercially available starting materials.

SUBMITTER: Faltracco M 

PROVIDER: S-EPMC6760471 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

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