Unknown

Dataset Information

0

Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis.


ABSTRACT: The interplay between signalling pathways and metabolism is crucial for tissue growth. Yet, it remains poorly understood. Here, we studied the consequences of modulating iron metabolism on the growth of Drosophila imaginal discs. We find that reducing the levels of the ferritin heavy chain in the larval wing discs leads to drastic growth defects, whereas light chain depletion causes only minor defects. Mutant cell clones for the heavy chain lack the ability to compete against Minute mutant cells. Reactive oxygen species (ROS) accumulate in wing discs with reduced heavy chain levels, causing severe mitochondrial defects and ferroptosis. Preventing ROS accumulation alleviates some of the growth defects. We propose that the increased expression of ferritin in hippo mutant cells may protect against ROS accumulation.

SUBMITTER: Mumbauer S 

PROVIDER: S-EPMC6786644 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7463707 | BioStudies
2007-01-01 | S-EPMC2892850 | BioStudies
2012-01-01 | S-EPMC3368869 | BioStudies
2019-01-01 | S-EPMC6917665 | BioStudies
1000-01-01 | S-EPMC3817156 | BioStudies
1000-01-01 | S-EPMC4434816 | BioStudies
2016-01-01 | S-EPMC4688087 | BioStudies
2020-01-01 | S-EPMC7452134 | BioStudies
2021-10-18 | E-MTAB-7451 | BioStudies
2020-01-01 | S-EPMC7492296 | BioStudies