Dataset Information


Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases.

ABSTRACT: BACKGROUND:Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region-specific thickness analysis of retinal layers could improve the detection of macular atrophy and unravel its association with visual disability in Parkinson's disease. METHODS:Patients with idiopathic Parkinson's disease (n = 63), dementia with Lewy bodies (n = 8), and E46K mutation carriers in the ?-synuclein gene (E46K-SNCA) (n = 4) and 34 controls underwent Spectralis optical coherence tomography macular scans and a comprehensive battery of visual function and cognition tests. We computed mean retinal layer thicknesses of both eyes within 1-, 2-, 3-, and 6-mm diameter macular discs and in concentric parafoveal (1- to 2-mm, 2- to 3-mm, 1- to 3-mm) and perifoveal (3- to 6-mm) rings. Group differences in imaging parameters and their relationship with visual outcomes were analyzed. A multivariate logistic model was developed to predict visual impairment from optical coherence tomography measurements in Parkinson's disease, and cutoff values were determined with receiver operating characteristic analysis. RESULTS:When compared with controls, patients with dementia with Lewy bodies had significant thinning of the ganglion cell-inner plexiform layer complex within the central 3-mm disc mainly because of differences in 1- to 3-mm parafoveal thickness. This parameter was strongly correlated in patients, but not in controls, with low contrast visual acuity and visual cognition outcomes (P

SUBMITTER: Murueta-Goyena A 

PROVIDER: S-EPMC6790692 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5519274 | BioStudies
2020-01-01 | S-EPMC7010471 | BioStudies
2017-01-01 | S-EPMC5535290 | BioStudies
2015-01-01 | S-EPMC4408212 | BioStudies
2019-01-01 | S-EPMC6544971 | BioStudies
1000-01-01 | S-EPMC4429276 | BioStudies
2018-01-01 | S-EPMC5937759 | BioStudies
2020-01-01 | S-EPMC7230595 | BioStudies
2020-01-01 | S-EPMC7035510 | BioStudies
2019-01-01 | S-EPMC6401083 | BioStudies