Dataset Information


Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy.

ABSTRACT: Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (?120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy.


PROVIDER: S-EPMC6839587 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

2019-01-01 | S-EPMC6691582 | BioStudies
2019-01-01 | S-EPMC6592180 | BioStudies
1000-01-01 | S-EPMC5706098 | BioStudies
1000-01-01 | S-EPMC5101891 | BioStudies
1000-01-01 | S-EPMC6181830 | BioStudies
2012-01-01 | S-EPMC3373296 | BioStudies
2017-01-01 | S-EPMC5566102 | BioStudies
2018-01-01 | S-EPMC5743840 | BioStudies
2020-01-01 | S-EPMC6929613 | BioStudies
2018-01-01 | S-EPMC6299436 | BioStudies