Dataset Information


Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid.

ABSTRACT: The variety and complexity of DNA-based structures make them attractive candidates for nanotechnology, yet insufficient stability and mechanical rigidity, compared to polyamide-based molecules, limit their application. Here, we combine the advantages of polyamide materials and the structural patterns inspired by nucleic-acids to generate a mechanically rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with diverse morphology and photoluminescent properties. The assembly possesses a unique atomic structure, with each guanine head of one molecule hydrogen bonded to the Fmoc carbonyl tail of another molecule, generating a non-planar cyclic quartet arrangement. This structure exhibits an average stiffness of 69.6 ± 6.8 N m-1 and Young's modulus of 17.8 ± 2.5 GPa, higher than any previously reported nucleic acid derived structure. This data suggests that the unique cation-free "basket" formed by the Fmoc-G-PNA conjugate can serve as an attractive component for the design of new materials based on PNA self-assembly for nanotechnology applications.

PROVIDER: S-EPMC6868146 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC7891605 | BioStudies
| S-EPMC5802362 | BioStudies
| S-EPMC5612497 | BioStudies
| S-EPMC8722525 | BioStudies
| S-EPMC4102141 | BioStudies
| S-EPMC2702766 | BioStudies
| S-EPMC2763603 | BioStudies
| S-EPMC7289805 | BioStudies
| S-EPMC136084 | BioStudies
| S-EPMC4134252 | BioStudies