Unknown

Dataset Information

0

Antihypertensive drugs and pancreatic cancer risk in patients with chronic pancreatitis: a Danish nationwide population-based cohort study.


ABSTRACT: BACKGROUND:Antihypertensives may inhibit pancreatic carcinogenesis. We examined the association between use of these drugs and pancreatic cancer in patients with chronic pancreatitis. METHODS:We conducted a nationwide population-based cohort study of all chronic pancreatitis patients diagnosed in Denmark during 1996-2012. Using a Cox proportional hazards model with time-varying exposure lagged by 1 year, we examined the risk of pancreatic cancer according to antihypertensive drug use. RESULTS:We included 8,311 patients with chronic pancreatitis and observed 153 pancreatic cancers during follow-up. At baseline, 2197 patients (26.4%) were exposed to at least one class of antihypertensive drugs. We did not observe any measurable associations between the use of antihypertensive drugs and pancreatic cancer. CONCLUSIONS:Our findings suggest little evidence of an association between the use of antihypertensive drugs and pancreatic cancer risk in patients with chronic pancreatitis. Confirmation is warranted in future studies.

SUBMITTER: Kirkegard J 

PROVIDER: S-EPMC6889405 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5220144 | BioStudies
2017-01-01 | S-EPMC5651316 | BioStudies
2018-01-01 | S-EPMC5997621 | BioStudies
2013-01-01 | S-EPMC3676446 | BioStudies
2015-01-01 | S-EPMC4633443 | BioStudies
2007-01-01 | S-EPMC1774562 | BioStudies
2017-01-01 | S-EPMC5235923 | BioStudies
2013-01-01 | S-EPMC4506757 | BioStudies
1000-01-01 | S-EPMC1735930 | BioStudies
1000-01-01 | S-EPMC4017930 | BioStudies