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Lower HbA1c in patients with type 1 diabetes and celiac disease who reached celiac-specific antibody-negativity-A multicenter DPV analysis.


ABSTRACT: OBJECTIVES:To study celiac-specific antibody status over 3?years in patients with type 1 diabetes and biopsy-proven celiac disease (T1D?+?CD). Furthermore, to determine clinical differences after diagnosis between patients reaching constant antibody-negativity (Ab-neg) and staying antibody-positive (Ab-pos). METHODS:A total of 608 pediatric T1D?+?CD patients from the multicenter DPV registry were studied longitudinally regarding their CD specific antibody-status. Differences between Ab-neg (n = 218) and Ab-pos (n = 158) patients 3?years after biopsy were assessed and compared with 26?833 T1D patients without CD by linear and logistic regression adjusted for age, gender, diabetes duration and migration background. RESULTS:Thirty-six percent of T1D?+?CD patients reached and sustained antibody-negativity 3?years after CD diagnosis. The median time until patients returned to Ab-neg was 0.86 (0.51;1.16) years. Three years after diagnosis, HbA1c was lowest in Ab-neg and highest in Ab-pos patients compared to T1D-only patients (adjusted mean (95%CI): 7.72 (7.51-7.92) % vs 8.44 (8.20-8.68) % vs 8.19 (8.17-8.21) %, adjusted P?

SUBMITTER: Nagl K 

PROVIDER: S-EPMC6899993 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

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