Unknown

Dataset Information

0

The prophylactic effects of long-acting granulocyte colony-stimulating factor for febrile neutropenia in newly diagnosed patients with epithelial ovarian cancer: a randomised controlled study.


ABSTRACT: OBJECTIVE:This study explored the prophylactic effects of long-acting granulocyte colony-stimulating factor (G-CSF) for febrile neutropenia (FN) in newly diagnosed patients with epithelial ovarian cancer (EOC). METHODS:Patients were randomised into a study group (long-acting G-CSF for all chemotherapy cycles) and a control group (short-acting G-CSF for first cycle and treatment per physician discretion for subsequent cycles) at a ratio of 1:2. The incidences of FN and myelosuppression and the number of clinical visits, medication doses, complete blood count (CBC) tests and adverse events were compared between the two groups. A regression model was used to determine the risk factors for FN. RESULTS:From 30 November 2018 to 1 April 2019, 84 cases were included in the final analysis; there were 24 (28.6%) and 60 (71.4%) patients in the study and control groups, respectively, and 605 chemotherapy cycles. The study group or chemotherapy cycles utilising long-acting G-CSF had significantly fewer utilisations and doses of short-acting G-CSF; clinical visits; CBC tests; and incidences of FN and myelosuppression; and less G-CSF-associated pain. The utilisation of G-CSF was the only independent factor for FN in a binary regression model. CONCLUSION:Long-acting G-CSF could effectively reduce the incidences of FN and myelosuppression and had mild adverse effects in newly diagnosed patients with EOC receiving chemotherapy. TRIAL REGISTRATION NUMBER:NCT03740464.

SUBMITTER: Li L 

PROVIDER: S-EPMC6923945 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7378111 | BioStudies
2015-01-01 | S-EPMC4584106 | BioStudies
2019-01-01 | S-EPMC6814815 | BioStudies
2020-01-01 | S-EPMC6954143 | BioStudies
2019-01-01 | S-EPMC6688232 | BioStudies
2015-01-01 | S-EPMC4559026 | BioStudies
2019-01-01 | S-EPMC6803220 | BioStudies
2020-01-01 | S-EPMC7211191 | BioStudies
2017-01-01 | S-EPMC5759943 | BioStudies
2014-01-01 | S-EPMC3913845 | BioStudies