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Ligand Controlled Ir-Catalyzed Regiodivergent Oxyamination of Unactivated Alkenes.


ABSTRACT: An intramolecular Ir(III)-catalyzed regiodivergent oxyamination of unactivated alkenes provides valuable ?-lactams, ?-lactones and ?-lactams. The regioselectivity is controlled by the electronically tunable cyclopentadienyl Ir(III)-complexes enabling oxyamination via either 5-exo or 6-endo pathways. With respect to the mechanism, we propose a highly reactive [3.1.0] bicycle intermediate derived from Ir(V) nitrene-mediated aziridination to be a key intermediate toward the synthesis of ?-lactams.

PROVIDER: S-EPMC6980349 | BioStudies |

REPOSITORIES: biostudies

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