Unknown

Dataset Information

0

Rosmarinus officinalis Essential Oil Improves Scopolamine-Induced Neurobehavioral Changes via Restoration of Cholinergic Function and Brain Antioxidant Status in Zebrafish (Danio rerio).


ABSTRACT: Rosmarinus officinalis L. is a traditional herb with various therapeutic applications such as antibacterial, antioxidant, anti-inflammatory, antidepressant, and anticholinesterase activities, and can be used for the prevention or treatment of dementia. In the present study, we tested whether Rosmarinus officinalis L. could counteract scopolamine-induced anxiety, dementia, and brain oxidative stress in the zebrafish model and tried to find the underlying mechanism. Rosmarinus officinalis L. essential oil (REO: 25, 150, and 300 µL/L) was administered by immersion to zebrafish (Danio rerio) once daily for eight days while scopolamine (100 µM) treatment was delivered 30 min before behavioral tests. The antidepressant and cognitive-enhancing actions of the essential oil in the scopolamine zebrafish model was measured in the novel tank diving test (NTT) and Y-maze test. The chemical composition was identified by Gas chromatograph-Mass spectrometry (GC-MS) analysis. The brain oxidative status and acetylcholinesterase (AChE) activity was also determined. REO reversed scopolamine-induced anxiety, memory impairment, and brain oxidative stress. In addition, a reduced brain AChE activity following the administration of REO in scopolamine-treated fish was observed. In conclusion, REO exerted antidepressant-like effect and cognitive-enhancing action and was able to abolish AChE alteration and brain oxidative stress induced by scopolamine.

SUBMITTER: Capatina L 

PROVIDER: S-EPMC7023291 | BioStudies | 2020-01-01

SECONDARY ACCESSION(S): 10.18433/J3PW38

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7694219 | BioStudies
2017-01-01 | S-EPMC5761036 | BioStudies
2020-01-01 | S-EPMC7356759 | BioStudies
1000-01-01 | S-EPMC4580266 | BioStudies
2013-01-01 | S-EPMC3874002 | BioStudies
2018-01-01 | S-EPMC5974226 | BioStudies
2020-01-01 | S-EPMC7180932 | BioStudies
2020-01-01 | S-EPMC7181224 | BioStudies
2013-01-01 | S-EPMC3705814 | BioStudies
2016-01-01 | S-EPMC4849071 | BioStudies