Ontology highlight
ABSTRACT:
SUBMITTER: Chandradoss KR
PROVIDER: S-EPMC7036197 | BioStudies | 2020-01-01
SECONDARY ACCESSION(S): 10.15252/msb.20156492
REPOSITORIES: biostudies
Fraser James J Ferrai Carmelo C Chiariello Andrea M AM Schueler Markus M Rito Tiago T Laudanno Giovanni G Barbieri Mariano M Moore Benjamin L BL Kraemer Dorothee C A DC Aitken Stuart S Xie Sheila Q SQ Morris Kelly J KJ Itoh Masayoshi M Kawaji Hideya H Jaeger Ines I Hayashizaki Yoshihide Y Carninci Piero P Forrest Alistair R R AR Semple Colin A CA Dostie Josée J Pombo Ana A Nicodemi Mario M
Molecular systems biology 20151223 12
Mammalian chromosomes fold into arrays of megabase-sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA. TADs have internal substructures that are often cell type specific, but their higher-order organization remains elusive. Here, we investigate TAD higher-order interactions with Hi-C through neuronal differentiation and show that they form a hierarchy of domains-within-domains (metaTADs) extending across genomic scales ...[more]