Dataset Information


Mesenchymal Stem Cells Beyond Regenerative Medicine.

ABSTRACT: Mesenchymal stem cells (MSCs) are competent suitors of cellular therapy due to their therapeutic impact on tissue degeneration and immune-based pathologies. Additionally, their homing and immunomodulatory properties can be exploited in cancer malignancies to transport pharmacological entities, produce anti-neoplastic agents, or induce anti-tumor immunity. Herein, we create a portfolio for MSC properties, showcasing their distinct multiple therapeutic utilities and successes/challenges thereof in both animal studies and clinical trials. We further highlight the promising potential of MSCs not only in cancer management but also in instigating tumor-specific immunity - i.e., cancer vaccination. Finally, we reflect on the possible reasons impeding the clinical advancement of MSC-based cancer vaccines to assist in contriving novel methodologies from which a therapeutic milestone might emanate.


PROVIDER: S-EPMC7040370 | BioStudies | 2020-01-01

SECONDARY ACCESSION(S): 10.18632/oncotarget.12678

REPOSITORIES: biostudies

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Resistance to neoplastic transformation of ex-vivo expanded human mesenchymal stromal cells after exposure to supramaximal physical and chemical stress.

Conforti Antonella A   Starc Nadia N   Biagini Simone S   Tomao Luigi L   Pitisci Angela A   Algeri Mattia M   Sirleto Pietro P   Novelli Antonio A   Grisendi Giulia G   Candini Olivia O   Carella Cintia C   Dominici Massimo M   Locatelli Franco F   Bernardo Maria Ester ME  

Oncotarget 20161101 47

The risk of malignant transformation of ex-vivo expanded human mesenchymal stromal cells (huMSCs) has been debated in the last years; however, the biosafety of these cells after exposure to supramaximal physical and chemical stress has never been systematically investigated.We established an experimental in vitro model to induce supramaximal physical (ionizing radiation, IR) and chemical (starvation) stress on ex-vivo expanded bone marrow (BM)-derived huMSCs and investigated their propensity to  ...[more]

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