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Mental disorders and weight change in a prospective study of bariatric surgery patients: 7 years of follow-up.


ABSTRACT: BACKGROUND:Long-term, longitudinal data are limited on mental disorders after bariatric surgery. OBJECTIVE:To report mental disorders through 7 years postsurgery and examine their relationship with changes in weight and health-related quality of life. SETTING:Three U.S. academic medical centers. METHOD:As a substudy of the Longitudinal Assessment of Bariatric Surgery Consortium, 199 adults completed the structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition prior to Roux-en-Y gastric bypass (RYGB) or laparoscopic adjustable gastric band. Participants who completed ?1 follow-up through 7 years postsurgery are included (n?=?173; 86.9%). Mixed models were used to examine mental disorders over time, and among the RYGB subgroup (n?=?104), their relationship with long-term (?4 yr) pre- to postsurgery changes in weight and health-related quality of life, measured with the Short Form-36 Health Survey, and with weight regain from nadir. RESULTS:Compared with presurgery (34.7%), the prevalence of having any mental disorder was significantly lower 4 years (21.3%; P < .01) and 5 years (19.2%; P?=?.01), but not 7 years (29.1%; P?=?.27) after RYGB. The most common disorders were not related to long-term weight loss postRYGB. However, independent of weight change, mood and anxiety disorders, both pre- and postRYGB, were significantly related to less improvement in mental (but not physical) health-related quality of life. Having a concurrent mood disorder appeared to be associated with greater weight regain (6.4% of maximum weight lost, 95% confidence interval, -.3 to 13.1), but this was not statistically significant (P?=?.06). CONCLUSIONS:Bariatric surgery does not result in consistent long-term reductions in mental disorders. Mood disorders may impact long-term outcomes of bariatric surgery.

SUBMITTER: Kalarchian MA 

PROVIDER: S-EPMC7045720 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

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