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The propionic acid and butyric acid in serum but not in feces are increased in patients with diarrhea-predominant irritable bowel syndrome.


ABSTRACT: BACKGROUND:Short-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting. Our study aims to explore the alteration of SCFAs in patients with diarrhea-predominant IBS (IBS-D) and their potential role in the occurrence and development of IBS. METHODS:We recruited patients with IBS-D defined by Rome IV criteria and age-and-gender matched healthy controls (HCs). A headspace solid-phase microextraction gas chromatography-mass spectrometric (HS-SPME-GC-MS) method was developed for the analysis of acetic, propionic and butyric acid in feces and serum. RESULTS:Compared with HCs, the levels of the serum propionate (2.957?±?0.157 vs 2.843?±?0.098?mmol/L, P?=?0.012) and butyrate (2.798?±?0.126 vs 2.697?±?0.077?mmol/L, P?=?0.012) were significantly higher in IBS-D group. No significant differences were found among two groups with regard to the concentration of fecal acetate (4.953?±?1.065 vs 4.774?±?1.465?mg/g, P?=?0.679), propionate (6.342?±?1.005 vs 6.282?±?1.077?mg/g, P?=?0.868) and butyrate (2.984?±?0.512 vs 3.071?±?0.447?mg/g, P?=?0.607). CONCLUSIONS:Metabolites of gut microbiota, the propionic and butyric acid, are increased in patients with IBS-D in serum but not in feces. It suggests that propionic and butyric acid might be associated with the occurrence and development of IBS.

SUBMITTER: Tian Z 

PROVIDER: S-EPMC7077160 | BioStudies | 2020-01-01

SECONDARY ACCESSION(S): 10.14309/ctg.0000000000000012

REPOSITORIES: biostudies

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