Stereoselective Allylic Alkylations of Amino Ketones and Their Application in the Synthesis of Highly Functionalized Piperidines.
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ABSTRACT: Chelated ketone enolates are excellent nucleophiles for allylic alkylations. Electron-withdrawing groups on the allyl moiety allow subsequent intramolecular Michael additions giving rise to piperidines with up to five stereogenic centers.
SUBMITTER: Prudel C
PROVIDER: S-EPMC7079034 | BioStudies | 2020-01-01
REPOSITORIES: biostudies
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