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Modulation of K+ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides.


ABSTRACT: Fast N-type inactivation of voltage-gated K+ (Kv) channels is important in fine-tuning of cellular excitability. To serve diverse cellular needs, N-type inactivation is regulated by numerous mechanisms. Here, we address how reactive sulfur species-the gaseous messenger H2S and polysulfides-affect N-type inactivation of the mammalian Kv channels Kv1.4 and Kv3.4. In both channels, the H2S donor NaHS slowed down inactivation with varying potency depending on the "aging" of NaHS solution. Polysulfides were >?1000 times more effective than NaHS with the potency increasing with the number of sulfur atoms (Na2S2 

PROVIDER: S-EPMC7086210 | BioStudies |

REPOSITORIES: biostudies

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