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Semisynthesis and Biological Evaluation of Platensimycin Analogues with Varying Aminobenzoic Acids.

ABSTRACT: Platensimycin (PTM) is an excellent natural product drug lead against various gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. In this study, twenty PTM derivatives with varying aminobenzoic acids were semisynthesized. In contrast to all the previous reported inactive aminobenzaote analogues, a few of them showed moderate antibacterial activities against S. aureus. Our study suggested that modification of the conserved aminobenzoic acid remains a viable approach to diversify the PTM scaffold.

SUBMITTER: Tian K

PROVIDER: S-EPMC7105086 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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