Semisynthesis and Biological Evaluation of Platensimycin Analogues with Varying Aminobenzoic Acids.
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ABSTRACT: Platensimycin (PTM) is an excellent natural product drug lead against various gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. In this study, twenty PTM derivatives with varying aminobenzoic acids were semisynthesized. In contrast to all the previous reported inactive aminobenzaote analogues, a few of them showed moderate antibacterial activities against S. aureus. Our study suggested that modification of the conserved aminobenzoic acid remains a viable approach to diversify the PTM scaffold.
SUBMITTER: Tian K
PROVIDER: S-EPMC7105086 | BioStudies | 2018-01-01
REPOSITORIES: biostudies
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