Dataset Information


Distribution Patterns of DNA N6-Methyladenosine Modification in Non-coding RNA Genes.

ABSTRACT: N6-methyladenosine (6mA) DNA modification played an important role in epigenetic regulation of gene expression. And the aberrational expression of non-coding genes, as important regular elements of gene expression, was related to many diseases. However, the distribution and potential functions of 6mA modification in non-coding RNA (ncRNA) genes are still unknown. In this study, we analyzed the 6mA distribution of ncRNA genes and compared them with protein-coding genes in four species (Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, and Homo sapiens) using single-molecule real-time (SMRT) sequencing data. The results indicated that the consensus motifs of short nucleotides at 6mA location were highly conserved in four species, and the non-coding gene was less likely to be methylated compared with protein-coding gene. Especially, the 6mA-methylated lncRNA genes were expressed significant lower than genes without methylation in A. thaliana (p = 3.295e-4), D. melanogaster (p = 3.439e-11), and H. sapiens (p = 9.087e-3).. The detection and distribution profiling of 6mA modification in ncRNA regions from four species reveal that 6mA modifications may have effects on their expression level.

PROVIDER: S-EPMC7105833 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC6967393 | BioStudies
| S-EPMC6553526 | BioStudies
| S-EPMC7997441 | BioStudies
| S-EPMC6211444 | BioStudies
| E-GEOD-68027 | BioStudies
| S-EPMC4499142 | BioStudies
| S-EPMC6582544 | BioStudies
| S-EPMC6052889 | BioStudies
2019-01-01 | S-EPMC6572862 | BioStudies
| S-EPMC7924747 | BioStudies