Unknown

Dataset Information

0

Kobuviruses carried by Rattus norvegicus in Guangdong, China.


ABSTRACT: BACKGROUND:Murine kobuviruses (MuKV) are newly recognized picornaviruses first detected in murine rodents in the USA in 2011. Little information on MuKV epidemiology in murine rodents is available. Therefore, we conducted a survey of the prevalence and genomic characteristics of rat kobuvirus in Guangdong, China. RESULTS:Fecal samples from 223 rats (Rattus norvegicus) were collected from Guangdong and kobuviruses were detected in 12.6% (28) of samples. Phylogenetic analysis based on partial 3D and complete VP1 sequence regions showed that rat kobuvirus obtained in this study were genetically closely related to those of rat/mouse kobuvirus reported in other geographical areas. Two near full-length rat kobuvirus genomes (MM33, GZ85) were acquired and phylogenetic analysis of these revealed that they shared very high nucleotide/amino acids identity with one another (95.4%/99.4%) and a sewage-derived sequence (86.9%/93.5% and 87.5%/93.7%, respectively). Comparison with original Aichivirus A strains, such human kobuvirus, revealed amino acid identity values of approximately 80%. CONCLUSION:Our findings indicate that rat kobuvirus have distinctive genetic characteristics from other Aichivirus A viruses. Additionally, rat kobuvirus may spread via sewage.

SUBMITTER: You FF 

PROVIDER: S-EPMC7161169 | BioStudies | 2020-01-01

SECONDARY ACCESSION(S): AB040749

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC7117211 | BioStudies
2018-01-01 | S-EPMC5810437 | BioStudies
2013-01-01 | S-EPMC7088707 | BioStudies
2013-01-01 | S-EPMC3814603 | BioStudies
2016-01-01 | S-EPMC5115164 | BioStudies
2014-01-01 | S-EPMC7086952 | BioStudies
2014-01-01 | S-EPMC4094370 | BioStudies
2013-01-01 | S-EPMC7127238 | BioStudies
2015-01-01 | S-EPMC7117564 | BioStudies
2019-01-01 | S-EPMC6318353 | BioStudies