Unknown

Dataset Information

0

Roles of the vagina and the vaginal microbiota in urinary tract infection: evidence from clinical correlations and experimental models.


ABSTRACT: Mounting evidence indicates that the vagina can harbor uropathogenic bacteria. Here, we consider three roles played by the vagina and its bacterial inhabitants in urinary tract infection (UTI) and urinary health. First, the vagina can serve as a reservoir for Escherichia coli, the most common cause of UTI, and other recognized uropathogens. Second, several vaginal bacterial species are frequently detected upon urine culture but are underappreciated as uropathogens, and other vaginal species are likely under-reported because of their fastidious nature. Third, some vaginal bacteria that are not widely viewed as uropathogens can transit briefly in the urinary tract, cause injury or immunomodulation, and shift the balance of host-pathogen interactions to influence the outcomes of uropathogenesis. This chapter describes the current literature in these three areas and summarizes the impact of the vaginal microbiota on susceptibility to UTI and other urologic conditions.

SUBMITTER: Lewis AL 

PROVIDER: S-EPMC7186798 | BioStudies | 2020-01-01

SECONDARY ACCESSION(S): 10.7453/gahmj.2013.061

REPOSITORIES: biostudies

Similar Datasets

2006-01-01 | S-EPMC1489509 | BioStudies
2020-01-01 | S-EPMC7272400 | BioStudies
2018-01-01 | S-EPMC6527134 | BioStudies
2018-01-01 | S-EPMC5908147 | BioStudies
2019-01-01 | S-EPMC6712402 | BioStudies
2019-01-01 | S-EPMC6758950 | BioStudies
1000-01-01 | S-EPMC5763535 | BioStudies
2019-01-01 | S-EPMC6425166 | BioStudies
2019-01-01 | S-EPMC7350877 | BioStudies
2017-01-01 | S-EPMC5328488 | BioStudies