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Association between respiratory syncytial virus hospitalization in infancy and childhood asthma.


ABSTRACT: INTRODUCTION:Respiratory syncytial virus infection in early childhood has been linked to longer-term respiratory morbidity; however, debate persists around its impact on asthma. The objective was to assess the association between respiratory syncytial virus hospitalization and childhood asthma. METHODS:Asthma hospital admissions and medication use through 18 years were compared in children with (cases) and without (controls) respiratory syncytial virus hospitalization in the first 2 years of life. All children born in National Health Service Scotland between 1996 and 2011 were included. RESULTS:Of 740?418 children (median follow-up: 10.6 years), 15?795 (2.1%) had a respiratory syncytial virus hospitalization at ?2 years (median age: 143 days). Asthma hospitalizations were three-fold higher in cases than controls (8.4% vs 2.4%; relative risk: 3.3, 95% confidence interval [CI]: 3.1-3.5; P?

SUBMITTER: Coutts J 

PROVIDER: S-EPMC7187471 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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