Unknown

Dataset Information

0

Comparison of Target Recognition by TRAF1 and TRAF2.


ABSTRACT: Although TRAF1 and TRAF2 share common receptors and have extremely conserved amino acid residues, recent studies have shown that key differences in receptor binding preferences with different affinities exist, which might be important for their different functions in TRAF-mediated signal transduction. To better understand TRAF1 and TRAF2 signaling, we analyzed and compared their receptor binding-affinities. Our study revealed that TRADD, TANK, and caspase-2 bind to both TRAF1 and TRAF2 with different affinities in vitro. Sequence and structural analyses revealed that S454 on TRAF2 (corresponding to A369 of TRAF1) is critical for the binding of TRADD, and F347 on TRAF1 (corresponding to L432 of TRAF2) is a critical determinant for high affinity binding of TANK and caspase-2.

SUBMITTER: Kim CM 

PROVIDER: S-EPMC7215387 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

Similar Datasets

2010-01-01 | S-EPMC2855162 | BioStudies
2016-01-01 | S-EPMC4858697 | BioStudies
1000-01-01 | S-EPMC1171732 | BioStudies
1000-01-01 | S-EPMC1369231 | BioStudies
2010-01-01 | S-EPMC2938345 | BioStudies
1000-01-01 | S-EPMC38288 | BioStudies
2016-01-01 | S-EPMC4918428 | BioStudies
2010-01-01 | S-EPMC2857039 | BioStudies
2018-01-01 | S-EPMC6050072 | BioStudies
2020-01-01 | S-EPMC7593343 | BioStudies