Dataset Information


MicroRNA-1298-3p inhibits proliferation and invasion of glioma cells by downregulating Nidogen-1.

ABSTRACT: Glioma is the most prevalent tumor of the central nervous system. To identify differentially expressed miRNAs (DEMs) in gliomas of different grades, bioinformatics analysis was performed. The DEMs between low-grade gliomas (LGGs) and high-grade gliomas (HGGs) were identified by screening the Gene Expression Omnibus and The Cancer Genome Atlas databases using the LIMMA package. Six overlapping DEMs were identified by comparing LGGs and HGGs. Downregulation of miR-1298-3p correlated with poor overall survival rates in glioma patients. Overexpression of miR-1298-3p induced apoptosis of glioma cells and inhibited glioma cell proliferation, migration, and invasion. The basement membrane protein Nidogen-1 (NID1) was identified as a direct binding target of miR-1298-3p in glioma cells. MiR-1298-3p agonist downregulated the NID1 and vimentin levels, but upregulated the level of E-cadherin in glioma cells. Importantly, overexpression of miR-1298-3p induced apoptosis and reduced tumor growth in a mouse xenograft model of glioma. Our results show that miR-1298-3p functions as a tumor suppressor in glioma cells, and suggest that it might serve as a potential biomarker and therapeutic target in glioma patients.


PROVIDER: S-EPMC7244082 | BioStudies | 2020-01-01

SECONDARY ACCESSION(S): 10.18632/oncotarget.16145

REPOSITORIES: biostudies

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NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells.

Zhou Ya Y   Zhu Yuanyuan Y   Fan Xiaoyan X   Zhang Chundong C   Wang Yitao Y   Zhang Lian L   Zhang Huan H   Wen Tao T   Zhang Kaina K   Huo Xiao X   Jiang Xue X   Bu Youquan Y   Zhang Ying Y  

Oncotarget 20170501 20

Nidogen-1 (NID1) has been identified as a novel candidate diagnostic biomarker of ovarian cancer in our previous study. Nevertheless, the role of NID1 in the pathogenesis of ovarian cancer is unclear. In the present study, we demonstrated that NID1 was a mesenchymal associated gene and its high expression was significantly correlated with shorter overall survival of ovarian cancer patients. The ectopic expression of NID1 in OVCAR-3 cells revealed a epithelial-mesenchymal transition (EMT) phenoty  ...[more]

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