Unknown

Dataset Information

0

Covid-19: the renin-angiotensin system imbalance hypothesis.


ABSTRACT: The emergency of SARS-CoV-2 in China started a novel challenge to the scientific community. As the virus turns pandemic, scientists try to map the cellular mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin-angiotensin system (RAS) imbalance to explain clinical, laboratory and imaging findings on disease course. We believe that exaggerated activation of ACE/Angiotensin II (Ang II)/Angiotensin Type 1 (AT1) receptor RAS axis in line with reduction of ACE2/Angiotensin-(1-7)/Mas receptor may exert a pivotal role in the pathogenesis of Covid-19. In this perspective, we discuss potential mechanisms and evidence on this hypothesis.

SUBMITTER: Lanza K 

PROVIDER: S-EPMC7276636 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7525006 | BioStudies
2020-01-01 | S-EPMC7568848 | BioStudies
2020-01-01 | S-EPMC7330865 | BioStudies
2020-01-01 | S-EPMC7188049 | BioStudies
2020-01-01 | S-EPMC7227557 | BioStudies
2020-01-01 | S-EPMC7308773 | BioStudies
2020-01-01 | S-EPMC7458035 | BioStudies
2020-01-01 | S-EPMC7431661 | BioStudies
2020-01-01 | S-EPMC7658217 | BioStudies
2020-01-01 | S-EPMC7575117 | BioStudies