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Prognostic role of high cathepsin D expression in breast cancer: a systematic review and meta-analysis.


ABSTRACT: Background:High cathepsin D has been associated with poor prognosis in breast cancer; however, the results of many studies are controversial. Here, we assessed the association between high cathepsin D levels and worse breast cancer prognosis by conducting a meta-analysis. Methods:A comprehensive search strategy was used to search relevant literature in PUBMED and EMBASE by September 2018. The meta-analysis was performed in Review Manager 5.3 using hazard ratios (HRs) with 95% confidence intervals (CIs). Results:A total of 15,355 breast cancer patients from 26 eligible studies were included in this meta-analysis. Significant associations between elevated high cathepsin D and poor overall survival (OS) (HR?=?1.61, 95% CI: 1.35-1.92, p?

SUBMITTER: Kang J 

PROVIDER: S-EPMC7281710 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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