Unknown

Dataset Information

0

Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case report.


ABSTRACT: A young male clove cigarette smoker experienced spontaneous pneumothorax and later paraseptal emphysema was detected on high-resolution computed tomography (HRCT) scan without respiratory symptoms. Smoking is a known risk factor for emphysema. Paraseptal emphysema is a type of emphysema that rarely causes respiratory symptoms, nevertheless, usually accompanied by spontaneous pneumothorax. Interleukin 33 (IL-33) is an alarmin cytokine that belongs to the IL-1 family. The effects of IL-33 depend on its structure. In its mature form, it is a cytokine alarmin that binds to ST2 (suppression of tumorigenicity) receptors on the surface of macrophages and innate immune cells to drive Th1/Th2 immune responses, causing oxidative stress, and increased IL-33 production causes polarization of alveolar macrophages to an M2 phenotype. In this study, long-term exposure to clove cigarette smoke caused an increased serum level of IL-33 (43.72 pg/mL) and paucigranulocytic airway inflammation. In paucigranulocytic inflammation, IL-33 is involved in lung parenchymal damage presumably through oxidative stress, activation of alveolar macrophage and increased MMP12 secretion, resulting in alveolar destruction and airspace enlargement.

PROVIDER: S-EPMC7300223 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC4450117 | BioStudies
2014-01-01 | S-EPMC4153727 | BioStudies
| S-EPMC3752926 | BioStudies
| S-EPMC3882898 | BioStudies
| S-EPMC8689000 | BioStudies
| S-EPMC5879141 | BioStudies
| S-EPMC5130231 | BioStudies
| S-EPMC3680142 | BioStudies
| S-EPMC6487813 | BioStudies
| S-EPMC4936823 | BioStudies