Unknown

Dataset Information

0

Total Synthesis of Tri-, Hexa- and Heptasaccharidic Substructures of the O-Polysaccharide of Providencia rustigianii O34.


ABSTRACT: A general and efficient strategy for synthesis of tri-, hexa- and heptasaccharidic substructures of the lipopolysaccharide of Providencia rustigianii O34 is described. For the heptasaccharide seven different building blocks were employed. Special features of the structures are an ?-linked galactosamine and the two embedded ?-fucose units, which are either branched at positions-3 and -4 or further linked at their 2-position. Convergent strategies focused on [4+3], [3+4], and [4+2+1] couplings. Whereas the [4+3] and [3+4] coupling strategies failed the [4+2+1] strategy was successful. As monosaccharidic building blocks trichloroacetimidates and phosphates were employed. Global deprotection of the fully protected structures was achieved by Birch reaction.

SUBMITTER: Ahadi S 

PROVIDER: S-EPMC7318715 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

Similar Datasets

2008-01-01 | S-EPMC2446748 | BioStudies
2006-01-01 | S-EPMC1346635 | BioStudies
2013-01-01 | S-EPMC3885344 | BioStudies
2007-01-01 | S-EPMC1797372 | BioStudies
2014-01-01 | S-EPMC3931799 | BioStudies
2012-01-01 | S-EPMC3393513 | BioStudies
2020-01-01 | S-EPMC7652902 | BioStudies
2011-01-01 | S-EPMC3109104 | BioStudies
2012-01-01 | S-EPMC3542290 | BioStudies
| PRJNA66257 | ENA