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Access to highly substituted oxazoles by the reaction of ?-azidochalcone with potassium thiocyanate.


ABSTRACT: The reactivity of ?-azidochalcones has been explored for the preparation of highly substituted oxazoles via a 2H-azirine intermediate. The azidochalcones, when treated with potassium thiocyanate in the presence of potassium persulfate, lead to 2,4,5-trisubstituted oxazoles in good yields. Incidentally, 2-aminothiazoles are the products when ferric nitrate is employed instead of persulfate in the above reaction.

SUBMITTER: Harisha MB 

PROVIDER: S-EPMC7476590 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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