Access to highly substituted oxazoles by the reaction of ?-azidochalcone with potassium thiocyanate.
Ontology highlight
ABSTRACT: The reactivity of ?-azidochalcones has been explored for the preparation of highly substituted oxazoles via a 2H-azirine intermediate. The azidochalcones, when treated with potassium thiocyanate in the presence of potassium persulfate, lead to 2,4,5-trisubstituted oxazoles in good yields. Incidentally, 2-aminothiazoles are the products when ferric nitrate is employed instead of persulfate in the above reaction.
SUBMITTER: Harisha MB
PROVIDER: S-EPMC7476590 | BioStudies | 2020-01-01
REPOSITORIES: biostudies
ACCESS DATA