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The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis.

ABSTRACT: BACKGROUND:There are controversial results concerning the prognostic implication of TERT promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we investigated whether there are any interactions of these two genetic markers on the overall survival (OS) of glioma patients. METHODS:Electronic databases including PubMed and Web of Science were searched for relevant studies. Hazard ratio (HR) and its 95% confidence interval (CI) for OS adjusted for selected covariates were calculated from the individual patient data (IPD), Kaplan-Meier curve (KMC), or directly obtained from the included studies. RESULTS:A total of nine studies comprising 2819 glioma patients were included for meta-analysis. Our results showed that TERT promoter mutation was associated with a superior outcome in MGMT-methylated gliomas (HR?=?0.73; 95% CI?=?0.55-0.98; p-value?=?0.04), whereas this mutation was associated with poorer survival in gliomas without MGMT methylation (HR?=?1.86; 95% CI?=?1.54-2.26; p-value


PROVIDER: S-EPMC7504655 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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