Unknown

Dataset Information

0

FADS genetic and metabolomic analyses identify the ?5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.


ABSTRACT: Humans have undergone intense evolutionary selection to optimize their capacity to generate necessary quantities of long chain (LC-) polyunsaturated fatty acid (PUFA)-containing lipids. To better understand the impact of genetic variation within a locus of three FADS genes (FADS1, FADS2, and FADS3) on a diverse family of lipids, we examined the associations of 247 lipid metabolites (including four major classes of LC-PUFA-containing molecules and signaling molecules) with common and low-frequency genetic variants located within the FADS locus. Genetic variation in the FADS locus was strongly associated (p?

SUBMITTER: Reynolds LM 

PROVIDER: S-EPMC7522985 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC5874031 | BioStudies
2018-01-01 | S-EPMC6250987 | BioStudies
2018-01-01 | S-EPMC5832746 | BioStudies
2017-01-01 | S-EPMC5707637 | BioStudies
2011-01-01 | S-EPMC3144869 | BioStudies
2018-01-01 | S-EPMC6024808 | BioStudies
2011-01-01 | S-EPMC6860603 | BioStudies
2013-01-01 | S-EPMC3600399 | BioStudies
2014-01-01 | S-EPMC4004819 | BioStudies
2017-01-01 | S-EPMC5215697 | BioStudies