Dataset Information


Blood-brain barrier-penetrating siRNA nanomedicine for Alzheimer's disease therapy.

ABSTRACT: Toxic aggregated amyloid-? accumulation is a key pathogenic event in Alzheimer's disease (AD), which derives from amyloid precursor protein (APP) through sequential cleavage by BACE1 (?-site APP cleavage enzyme 1) and ?-secretase. Small interfering RNAs (siRNAs) show great promise for AD therapy by specific silencing of BACE1. However, lack of effective siRNA brain delivery approaches limits this strategy. Here, we developed a glycosylated "triple-interaction" stabilized polymeric siRNA nanomedicine (Gal-NP@siRNA) to target BACE1 in APP/PS1 transgenic AD mouse model. Gal-NP@siRNA exhibits superior blood stability and can efficiently penetrate the blood-brain barrier (BBB) via glycemia-controlled glucose transporter-1 (Glut1)-mediated transport, thereby ensuring that siRNAs decrease BACE1 expression and modify relative pathways. Noticeably, Gal-NP@siBACE1 administration restored the deterioration of cognitive capacity in AD mice without notable side effects. This "Trojan horse" strategy supports the utility of RNA interference therapy in neurodegenerative diseases.


PROVIDER: S-EPMC7546706 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC1635650 | BioStudies
2017-01-01 | S-EPMC6705717 | BioStudies
2016-01-01 | S-EPMC5043288 | BioStudies
2004-01-01 | S-EPMC2659546 | BioStudies
2018-01-01 | S-EPMC5987914 | BioStudies
2016-01-01 | S-EPMC4944430 | BioStudies
1000-01-01 | S-EPMC1693730 | BioStudies
2019-01-01 | S-EPMC6485359 | BioStudies
2010-01-01 | S-EPMC2909280 | BioStudies
2017-01-01 | S-EPMC5653456 | BioStudies