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Relation of High Lipoprotein (a) Concentrations to Platelet Reactivity in Individuals with and Without Coronary Artery Disease.


ABSTRACT: INTRODUCTION:Lipoprotein (a) [Lp(a)] is a risk factor for coronary artery disease (CAD). To the best of our knowledge, this is the first study addressing the relationship between Lp(a) and platelet reactivity in primary and secondary prevention. METHODS:Lp(a) was evaluated in 396 individuals with (82.3%) and without (17.7%) obstructive CAD. The population was divided into two groups according to Lp(a) concentrations with a cutoff value of 50 mg/dL. The primary objective was to evaluate the association between Lp(a) and adenosine diphosphate (ADP)-induced platelet reactivity using the VerifyNow™ P2Y12 assay. Platelet reactivity was also induced by arachidonic acid and collagen-epinephrine (C-EPI) and assessed by Multiplate™, platelet function analyzer™ 100 (PFA-100), and light transmission aggregometry (LTA) assays. Secondary objectives included the assessment of the primary endpoint in individuals with or without CAD. RESULTS:Overall, 294 (74.2%) individuals had Lp(a)??0.05). Finally, multivariable analysis did not show a significant association between ADP-induced platelet reactivity and Lp(a)???50 mg/dL [adjusted OR?=?1.00 [(95% CI 0.99-1.01), P?=?0.590]. CONCLUSION:In individuals with or without CAD, Lp(a)???50 mg/dL was not associated with higher platelet reactivity.

SUBMITTER: Salsoso R 

PROVIDER: S-EPMC7547998 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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