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Antibiotic affects the gut microbiota composition and expression of genes related to lipid metabolism and myofiber types in skeletal muscle of piglets.


ABSTRACT: BACKGROUND:Early-life antibiotic administration is known to affect gut microbiota and host adiposity, but the effects of antibiotic exposure on skeletal muscle properties remain unknown. The present study evaluated the changes in skeletal muscle properties including myofiber characteristics and composition, as well as intramuscular fat (IMF) content in skeletal muscle of piglets when exposed to a tylosin-containing diet. RESULTS:A total of 18 piglets (28?days of age) were randomly allocated into two groups: control basal diet (Control) and Control +?100?mg tylosin phosphate/kg of feed (Antibiotic). The trial lasted for 39?days. High-throughput amplicon sequencing revealed that no significant difference in initial gut microbiota composition was existed between Control and Antibiotic groups. Antibiotic administration increased body weight and growth rate and decreased feed to gain ratio of pigs (P?

SUBMITTER: Yan H 

PROVIDER: S-EPMC7568366 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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