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Effect of body mass index on response to neo-adjuvant therapy in HER2-positive breast cancer: an exploratory analysis of the NeoALTTO trial.


ABSTRACT: BACKGROUND:Obesity is a risk factor for breast cancer (BC) development, recurrence, and death. In view of this, we aimed to investigate the clinical value of obesity in BC patients treated with anti-HER2 therapies in the NeoALTTO trial, which randomized 455 patients to neo-adjuvant lapatinib, trastuzumab, or their combination plus paclitaxel. METHODS:Patients were classified according to their basal body mass index (BMI) into underweight (

SUBMITTER: Di Cosimo S 

PROVIDER: S-EPMC7590445 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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