Unknown

Dataset Information

0

Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model.


ABSTRACT: The Akt family is comprised of three unique homologous proteins with isoform-specific effects, but isoform-specific in vivo data are limited in follicular thyroid cancer (FTC), a PI3 kinase-driven tumor. Prior studies demonstrated that PI3K/Akt signaling is important in thyroid hormone receptor ?PV/PV knock-in (PV) mice that develop metastatic thyroid cancer that most closely resembles FTC. To determine the roles of Akt isoforms in this model we crossed Akt1-/-, Akt2-/-, and Akt3-/- mice with PV mice. Over 12 months, thyroid size was reduced for the Akt null crosses (p?

SUBMITTER: Saji M 

PROVIDER: S-EPMC7591514 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

Similar Datasets

2011-01-01 | S-EPMC3151477 | BioStudies
1000-01-01 | S-EPMC2851190 | BioStudies
2020-01-01 | S-EPMC7339265 | BioStudies
2014-01-01 | S-EPMC4010710 | BioStudies
2014-01-01 | S-EPMC4895609 | BioStudies
2013-01-01 | S-EPMC3749486 | BioStudies
2004-01-01 | S-EPMC385398 | BioStudies
2018-01-01 | S-EPMC6154455 | BioStudies
2011-01-01 | S-EPMC3086765 | BioStudies
2018-01-01 | S-EPMC6138525 | BioStudies