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Phylogenetic and whole genome analysis of first seven SARS-CoV-2 isolates in Bangladesh


ABSTRACT: Aim: Whole genome and peptide mutation analysis can specify effective vaccine and therapeutics against severe acute respiratory coronavirus-2 (SARS-CoV-2). Materials & methods: Whole genome similarity for Bangladeshi SARS-CoV-2 was determined using ClustalW and BLASTn. Phylogenetic analysis was conducted using neighbor-joining method. Results: 100% of isolates in Bangladesh were in the G clade. We found 99.98–100% sequence similarity among Bangladeshi isolates and isolates of England, Greece, USA, Saudi Arabia and India. Deletion of bases at 5? untranslated region and 3? untranslated region was detected. Substitution 261 (E?D) at NSP13 and 1109 (F?L) at spike (S) protein were detected. Substitution 377 (D?G) at nucleocapsid with common substitution 614 (D?G) at S were also detected. Conclusion: This study will provide baseline data for development of an effective vaccine or therapeutics against SARS-CoV-2. Graphical abstract

SUBMITTER: Sharif N 

PROVIDER: S-EPMC7692877 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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