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Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching.

ABSTRACT: Microcontainers are reservoir-based advanced drug delivery systems (DDS) that have proven to increase the bioavailibity of the small-molecule drugs, targeting of biomolecules, protection of vaccines and improved treatment of Pseudomonas aeruginosa. However, high-throughput loading of these micron-sized devices with drug has been challenging. Hot punching is a new technique that is a fast, simple and single-step process where the microdevices are themselves used as mold to punch biocompatible and biodegradable drug-polymer films, thereby loading the containers. Here, we investigate the effect of hot punching on the drug distribution as well as drug release from the loaded drug-polymer matrices. Zero-order sustained drug release is observed for the model drug Furosemide embedded in biodegradable polymer, Poly-?-caprolactone, which is attributed to the unique spatial distribution of Furosemide during the loading process.


PROVIDER: S-EPMC7692970 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

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