Dataset Information


How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices.

ABSTRACT: Purpose: To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively.

Methods: Computer models were used to simulate RFA with a 3-cm Cool-tip applicator and MWA with an Amica-Gen applicator. The Arrhenius model was used to compute the damage index (?). CZ was considered when ??>?4.6 (>99% of damaged cells). Regions with 0.6<??
Results: Ten-min RFA (51?W) created smaller periablational zones than 10-min MWA (11.3?cm3 vs. 17.2-22.9?cm3, for 60-100?W MWA, respectively). Prolonging duration from 5 to 10?min increased the PZ in MWA more than in RFA (2.7?cm3 for RFA vs. 8.3-11.9?cm3 for 60-100?W MWA, respectively). PZ/CZ for RFA were relatively high (65-69%), regardless of ablation time, while those for MWA were highly dependent on the duration (increase of up to 25% between 5 and 10?min) and on the applied power (smaller values as power was raised, 102% for 60?W vs. 81% for 100?W, both for 10?min). The lowest PZ/CZ across all settings was 56%, obtained with 100?W-5?min MWA.

Conclusions: Although RFA creates smaller periablational zones than MWA, 100?W-5?min MWA provides the lowest PZ/CZ.

PROVIDER: S-EPMC7714001 | BioStudies |

REPOSITORIES: biostudies

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