Dataset Information


The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furthermore, the crosstalk among PSCs, pancreatic cancer cells (PCCs) as well as other stroma cells can establish a growth-supportive tumor microenvironment (TME) of PDAC, thereby enhancing tumor growth, metastasis, and chemoresistance via various pathways. Recently, targeting stroma has emerged as a promising strategy for PDAC therapy, and several novel strategies have been proposed. The aim of our study is to give a profound review of the role of PSCs in PDAC progression and recent advances in stroma-targeting strategies.

PROVIDER: S-EPMC7841014 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC4294325 | BioStudies
| S-EPMC3097171 | BioStudies
| S-EPMC5944235 | BioStudies
| S-EPMC7016771 | BioStudies
| S-EPMC6565370 | BioStudies
| S-EPMC6580453 | BioStudies
| S-EPMC4671732 | BioStudies
| S-EPMC7761836 | BioStudies
| S-EPMC6826654 | BioStudies
| S-EPMC6107580 | BioStudies