Dataset Information


Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin.

ABSTRACT: The detailed mechanisms by which dopamine (DA) and serotonin (5-HT) act in the nucleus accumbens (NAc) to influence motivated behaviors in distinct ways remain largely unknown. Here, we examined whether DA and 5-HT selectively modulate excitatory synaptic transmission in NAc medium spiny neurons in an input-specific manner. DA reduced excitatory postsynaptic currents (EPSCs) generated by paraventricular thalamus (PVT) inputs but not by ventral hippocampus (vHip), basolateral amygdala (BLA), or medial prefrontal cortex (mPFC) inputs. In contrast, 5-HT reduced EPSCs generated by inputs from all areas except the mPFC. Release of endogenous DA and 5-HT by methamphetamine (METH) and (±)3,4-methylenedioxymethamphetamine (MDMA), respectively, recapitulated these input-specific synaptic effects. Optogenetic inhibition of PVT inputs enhanced cocaine-conditioned place preference, whereas mPFC input inhibition reduced the enhancement of sociability elicited by MDMA. These findings suggest that the distinct, input-specific filtering of excitatory inputs in the NAc by DA and 5-HT contribute to their discrete behavioral effects.

PROVIDER: S-EPMC8214692 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

2008-01-01 | S-EPMC2224217 | BioStudies
| S-EPMC4613616 | BioStudies
| S-EPMC9302453 | BioStudies
| S-EPMC6773659 | BioStudies
| S-EPMC5645740 | BioStudies
| S-EPMC5997539 | BioStudies
| S-EPMC2042207 | BioStudies
| S-EPMC3124246 | BioStudies
| S-EPMC4448554 | BioStudies
2006-01-01 | S-EPMC1413839 | BioStudies