Dataset Information


Performance of Ga-68 PSMA PET/CT for diagnosis and grading of local prostate cancer.



We aimed to evaluate the utility of prostate-specific membrane antigen (PSMA) PET/CT for the detection of local disease within the prostate.


This is a retrospective review of a single-center experience evaluating intraprostatic detection rates compared with final histopathology in a radical prostatectomy (RP) population. Seventy-two patients had PSMA PET/CT scan performed as part of their primary staging. Intraprostatic PSMA PET/CT avidity was assessed. PSMA PET/CT uptake was retrospectively correlated with patient characteristics including final histopathology, MRI Prostate Imaging Reporting and Data System (PI-RADS) score, clinical tumor stage, prostate-specific antigen (PSA) level, and patient age.


The sensitivity of PSMA PET/CT for the detection of RP-confirmed prostate cancer was 81.2%. Much higher sensitivity was found within certain subpopulations. The patient characteristics that most strongly correlated with focal intraprostatic PSMA PET/CT uptake were patient age (Kendall's tau coefficient τb = 0.24, p < 0.05) and clinical T stage (τb = 0.21, p < 0.05).The International Society of Urological Pathology (ISUP) grade group from final RP was predicted by standardized uptake value (SUVmax) and to a lesser extent PSA and the maximal dimension of PET-avid lesions. SUVmax monotonically increased with ISUP grade group. If SUVmax was above 10 g/mL, the final RP histopathology had a relative risk of 2.3 (95% CI 1.3-4.1) of being ISUP grade group 5.


This trial provides early evidence that PSMA PET/CT assists in the grading of prostate cancer and suggests that the imaging modality is particularly accurate in subpopulations including the elderly and those with palpable disease.

PROVIDER: S-EPMC8322807 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC9315142 | BioStudies
| S-EPMC8484204 | BioStudies
| S-EPMC8176856 | BioStudies
| S-EPMC8113179 | BioStudies
| S-EPMC8380207 | BioStudies
| S-EPMC7456174 | BioStudies
| S-EPMC8688644 | BioStudies
| S-EPMC9263625 | BioStudies
| S-EPMC9313142 | BioStudies
| S-EPMC8761183 | BioStudies