Dataset Information


Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration.

ABSTRACT: During injured tissue regeneration, the extracellular matrix plays a key role in controlling and coordinating various cellular events by binding and releasing secreted proteins in addition to promoting cell adhesion. Herein, we develop a cell-adhesive fiber-forming peptide that mimics the jigsaw-shaped hydrophobic surface in the dovetail-packing motif of glycophorin A as an artificial extracellular matrix for regenerative therapy. We show that the jigsaw-shaped self-assembling peptide forms several-micrometer-long supramolecular nanofibers through a helix-to-strand transition to afford a hydrogel under physiological conditions and disperses homogeneously in the hydrogel. The molecular- and macro-scale supramolecular properties of the jigsaw-shaped self-assembling peptide hydrogel allow efficient incorporation and sustained release of vascular endothelial growth factor, and demonstrate cell transplantation-free regenerative therapeutic effects in a subacute-chronic phase mouse stroke model. This research highlights a therapeutic strategy for injured tissue regeneration using the jigsaw-shaped self-assembling peptide supramolecular hydrogel.

PROVIDER: S-EPMC8604910 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC5882690 | BioStudies
| S-EPMC8429915 | BioStudies
2015-01-01 | S-EPMC4647837 | BioStudies
| S-EPMC7042674 | BioStudies
| S-EPMC7411710 | BioStudies
| S-EPMC2663994 | BioStudies
| S-EPMC7392527 | BioStudies
| S-EPMC6688848 | BioStudies
| S-EPMC5588550 | BioStudies
| S-EPMC4195521 | BioStudies