Dataset Information


NF-κB signaling in inflammation and cancer.

ABSTRACT: Since nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism of NF-κB for 35 years, which lead to significant progress. Meanwhile, the molecular mechanisms regulating NF-κB activation have also been illuminated, the cascades of signaling events leading to NF-κB activity and key components of the NF-κB pathway are also identified. It has been suggested NF-κB plays an important role in human diseases, especially inflammation-related diseases. These studies make the NF-κB an attractive target for disease treatment. This review aims to summarize the knowledge of the family members of NF-κB, as well as the basic mechanisms of NF-κB signaling pathway activation. We will also review the effects of dysregulated NF-κB on inflammation, tumorigenesis, and tumor microenvironment. The progression of the translational study and drug development targeting NF-κB for inflammatory diseases and cancer treatment and the potential obstacles will be discussed. Further investigations on the precise functions of NF-κB in the physiological and pathological settings and underlying mechanisms are in the urgent need to develop drugs targeting NF-κB for inflammatory diseases and cancer treatment, with minimal side effects.

PROVIDER: S-EPMC8706767 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

2011-01-01 | S-EPMC3193399 | BioStudies
2011-01-01 | S-EPMC3075605 | BioStudies
| S-EPMC9309093 | BioStudies
| S-EPMC8091601 | BioStudies
| S-EPMC8545986 | BioStudies
| S-EPMC8342216 | BioStudies
| S-EPMC4194146 | BioStudies
| S-EPMC8286839 | BioStudies
| S-EPMC8552041 | BioStudies
| S-EPMC7710137 | BioStudies