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B cell differentiation

ABSTRACT: A dynamic model for the regulatory network that controls terminal B cell differentiation

SUBMITTER: Akram Mendez

PROVIDER: 2394 | Cell Collective |

REPOSITORIES: Cell Collective

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A Network Model to Describe the Terminal Differentiation of B Cells.

Méndez Akram A Mendoza Luis L

PLoS computational biology 20160111 1

Terminal differentiation of B cells is an essential process for the humoral immune response in vertebrates and is achieved by the concerted action of several transcription factors in response to antigen recognition and extracellular signals provided by T-helper cells. While there is a wealth of experimental data regarding the molecular and cellular signals involved in this process, there is no general consensus regarding the structure and dynamical properties of the underlying regulatory network ...[more]

PMID: 26751566

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