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Colitis-associated colon cancer

ABSTRACT: This model looks at the development of colitis-associated colon cancer in order investigate the mechanism behind inflammation-associated tumorigenesis. Dynamic simulations reveal that P53, MDM2, and AKT may constitute a core network responsible for the malignant transformation of colon epithelial cells in a pro-tumor inflammatory environment. This model can aid in furthering mechanistic studies on colitis-associated colon cancer in addition to identifying novel cancer therapies.

SUBMITTER: Audrey Crowther

PROVIDER: 4601 | Cell Collective |

REPOSITORIES: Cell Collective

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Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.

Lu Junyan J Zeng Hanlin H Liang Zhongjie Z Chen Limin L Zhang Liyi L Zhang Hao H Liu Hong H Jiang Hualiang H Shen Bairong B Huang Ming M Geng Meiyu M Spiegel Sarah S Luo Cheng C

Scientific reports 20151008

The connection between inflammation and tumourigenesis has been well established. However, the detailed molecular mechanism underlying inflammation-associated tumourigenesis remains unknown because this process involves a complex interplay between immune microenvironments and epithelial cells. To obtain a more systematic understanding of inflammation-associated tumourigenesis as well as to identify novel therapeutic approaches, we constructed a knowledge-based network describing the development ...[more]

PMID: 26446703

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