CD4+ T cell Differentiation

ABSTRACT: The model includes 38 components and 96 biochemical interactions that regulate the differentiation process of major T cell subtypes, i.e., Th1, Th2, Th17 and iTreg cells. Individual components of the model represent lineage-specifying transcription factors (Tbet, GATA3, RORt, and Foxp3), STAT proteins, cytokines, their receptors, and other signaling molecules. The extracellular environment is represented in the model by eight cytokines and a (generic) TCR ligand known to play a role in T cell differentiation. PMID: 22871178

SUBMITTER: Bhanwar Lal Puniya 

PROVIDER: 6678 | Cell Collective |

REPOSITORIES: Cell Collective