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RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism

ABSTRACT:

RNA-Seq studies of Gene Expression in Cells and Networks in FI (fronto-insular) and AC (anterior cingulate) cortex in Autism. We seek to understand the cellular bases of autism by using a new technology, RNA-Seq, to determine differences in gene expression in autopsy brains of subjects with well described autism versus age and sex matched neurotypical individuals. We have investigated two specific cortical areas involved in self-awareness and social reciprocity which are abnormal in autism and have found increased expression in a network of genes related to inflammation in autism group A, whereas the remaining cases, autism group B, have increased expression in a network of genes related to synapses. The current dbGaP study release includes RNA sequencing and phenotype data of n=27 subjects of African - American, Caucasian, or Hispanic origin.

PROVIDER: phs000609 | dbGaP |

SECONDARY ACCESSION(S): PRJNA203309PRJNA203311

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs000609.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000609.Brains_GeneExpression.v1.p1.MULTI.pdf	Pdf
	manifest_phs000609.Brains_GeneExpression.v1.p1.c1.GRU.pdf	Pdf
	datadict_v2.xsl	Other

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RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism

Project description:<p> RNA-Seq studies of Gene Expression in Cells and Networks in FI (fronto-insular) and AC (anterior cingulate) cortex in Autism. We seek to understand the cellular bases of autism by using a new technology, RNA-Seq, to determine differences in gene expression in autopsy brains of subjects with well described autism versus age and sex matched neurotypical individuals. We have investigated two specific cortical areas involved in self-awareness and social reciprocity which are abnormal in autism and have found increased expression in a network of genes related to inflammation in autism group A, whereas the remaining cases, autism group B, have increased expression in a network of genes related to synapses. The current dbGaP study release includes RNA sequencing and phenotype data of n=27 subjects of African - American, Caucasian, or Hispanic origin. </p>

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