Regulatory Genomics of Human Embryonic Development

ABSTRACT:

We used epigenetic profiling to map active enhancers in the developing human limb and cortex as described in two published studies:

• Cotney J, Leng J, Yin J, Reilly SK et al. The evolution of lineage-specific regulatory activities in the human embryonic limb. Cell 2013;154(1):185-96.
• Reilly SK, Yin J, Ayoub AE, Emera D et al. Evolutionary changes in promoter and enhancer activity during human corticogenesis. Science 2015;347(6226):1155-9.

We also used ChIP-seq to map binding sites for the chromatin modifier CHD8 in the developing human brain, as described in one published study:

• Cotney J, Muhle RA, Sanders SJ, Liu L et al. The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. Nat Commun 2015;6:6404.

We are also depositing primary human sequence reads related to processed datasets in the Gene Expression Omnibus under the following accession numbers: GSE42413 (Cotney et al. 2013); GSE63649 (Reilly et al. 2015); GSE57369 (Cotney et al. 2015).

PROVIDER: phs001226 | dbGaP |

SECONDARY ACCESSION(S): PRJNA348388PRJNA348389

REPOSITORIES: dbGaP